In the year that marks the 150th anniversary of the birth of Oswaldo Cruz, the celebrations for the anniversary of Instituto Oswaldo Cruz (IOC/Fiocruz) highlighted the legacy of the institutional patron with the theme 'IOC 122 years: Oswaldo lives'. After two years of remote celebrations due to the Covid-19 pandemic, the events were marked by emotion and the reaffirmation of the commitment to science for public health in Brazil. The sessions took place on May 25, 2022, an anniversary shared by IOC and by Fiocruz, and May 27, in a hybrid way, with activities on the F campusiocruz in Manguinhos, in Rio de Janeiro, and broadcast live on Canal do IOC on YouTube (www.youtube.com.br/canalioc)