Since May 2022, cases of monkeypox have been reported in countries where the disease is not endemic. Belonging to the genus Orthopoxvirus, which also comprises the pathogens responsible for human and cowpox, infection with monkeypox virus (MPXV) causes swollen lymph nodes, the appearance of skin lesions, fever, weakness, and severe headaches and body aches. . The Enterovirus Laboratory of the IOC is a reference for laboratory diagnosis of suspected cases from throughout the Northeast region