In recent decades, dengue fever has ceased to be merely an endemic disease and has become one of the major contemporary challenges to global health, driven by the geographic expansion of the virus and the adaptation of its vector. Aedes aegypti to urban environments and the intensification of outbreaks and epidemics.
This is the starting point of the book 'Evolution of the dengue virus: from emergence to a global health crisis – Insights into genomics, ecology, and epidemiology'.
The work is edited by researchers Claudia Nunes Duarte, from Fiocruz Paraná, and Marta Giovanetti, from Laboratory of Arboviruses and Hemorrhagic Viruses from the Oswaldo Cruz Institute (IOC/Fiocruz).
The book brings together scientists from different fields and countries to present a comprehensive view of the biological, environmental, and social factors that shape the transmission dynamics of dengue fever.
According to Marta, who also works as a professor at the Campus Biomédico University in Rome, Italy, the main motivation was to organize, in a single volume, knowledge that is currently scattered across scientific articles and technical reports.
Given this scenario, the book aimed to construct a synthetic, critical, and applicable material capable of bridging the gap between scientific production and decision-making in public health.
“We seek to fill an important gap between the science produced and its practical application. Dengue requires an integrated approach, and the book was designed precisely to support both researchers and managers,” he explained.
The chapters were structured around themes considered central to understanding and addressing the disease today, such as transmission dynamics, environmental and urban factors, clinical spectrum, surveillance and diagnosis, viral evolution, and prevention strategies.
The selection of authors prioritized scientific backgrounds, experience in surveillance, and work in strategic areas, seeking complementarity between different profiles.
Representing the IOCThe document is signed by scientists Ana Maria Bispo de Filippis, Myrna Cristina Bonaldo, and Rafael Maciel de Freitas, in addition to Marta Giovanetti herself.
"The book helps guide priorities, such as where to invest, interpret early signs, and how to transform data, including genomic data, into faster and more targeted answers," said Marta.
“Our goal was to produce material that wouldn't be restricted to academia, but that could also support managers and health services in formulating more effective responses to the current complexity of dengue fever,” added Claudia Nunes Duarte.
The material was published by Springer Nature, one of the world's leading scientific publishing groups. For Claudia, the choice of two Brazilian researchers to edit the publication demonstrates the international recognition of dengue research conducted in the country.
"Springer Nature is a very selective publisher when choosing its themes and editors. The fact that we were invited demonstrates the leading role of Brazil and the Fioc"Cruze in the study of the disease," he highlighted.
From the historical rescue of dengue fever to the molecular mechanisms that sustain viral circulation, the work constructs a narrative that helps to understand how the arbovirus has established itself as one of the most adaptable pathogens today.
The initial chapters trace the evolutionary and phylogenetic paths of the dengue virus and describe the global dispersal of different lineages, which began circulating simultaneously in various territories.
The work then moves on to the cellular and immunological scale, detailing the interactions between virus and host, as well as the mechanisms that influence the clinical severity of the infection.
In parallel, it discusses the evolution of diagnostic techniques, vaccines, and antiviral strategies, reflecting the ongoing scientific effort to keep pace with the virus's adaptive capacity.
The discussion also brings vector surveillance, climate change, and genomic monitoring into the debate, highlighting that the evolution of dengue fever is not limited to biological aspects, but also involves environmental and social factors.
Throughout the chapters, the discussion focuses on disordered urban growth, human mobility, and adaptation to... Aedes aegypti These factors are emerging as creating increasingly favorable conditions for viral circulation, increasing the risk of large-scale epidemics.
On the other hand, the book highlights important advances in Brazil's capacity to produce applied science, expand surveillance networks, and incorporate genomics and integrated analysis into the routine of health services.
According to Marta, this movement paves the way for faster and more focused responses, as well as promoting innovation in vector control strategies and monitoring tools.
"There is room to strengthen evidence-based territorial responses, invest in new surveillance approaches, and transform data into concrete action," he reflected.
Claudia points out that, in 2024, Brazil recorded a historic peak in dengue cases, accompanied by an increase in mortality. For her, in this context of intensified transmission and greater epidemiological complexity, the book emerges as a strategic contribution to improving scientific and institutional responses.
"This work brings together the most up-to-date information in terms of research, vaccines, diagnosis, prophylaxis, and surveillance, contributing to addressing knowledge gaps and supporting more effective responses," he concluded.
Evolution of the dengue virus: from emergence to a global health crisis – Insights into genomics, ecology, and epidemiology
Springer Nature
389 pages
How to acquire:
• SpringerLink Platform (eBook and PDF, via institutional access or individual purchase)
• Springer Nature online store
In recent decades, dengue fever has ceased to be merely an endemic disease and has become one of the major contemporary challenges to global health, driven by the geographic expansion of the virus and the adaptation of its vector. Aedes aegypti to urban environments and the intensification of outbreaks and epidemics.
This is the starting point of the book 'Evolution of the dengue virus: from emergence to a global health crisis – Insights into genomics, ecology, and epidemiology'.
The work is edited by researchers Claudia Nunes Duarte, from Fiocruz Paraná, and Marta Giovanetti, from Laboratory of Arboviruses and Hemorrhagic Viruses from the Oswaldo Cruz Institute (IOC/Fiocruz).
The book brings together scientists from different fields and countries to present a comprehensive view of the biological, environmental, and social factors that shape the transmission dynamics of dengue fever.
According to Marta, who also works as a professor at the Campus Biomédico University in Rome, Italy, the main motivation was to organize, in a single volume, knowledge that is currently scattered across scientific articles and technical reports.
Given this scenario, the book aimed to construct a synthetic, critical, and applicable material capable of bridging the gap between scientific production and decision-making in public health.
“We seek to fill an important gap between the science produced and its practical application. Dengue requires an integrated approach, and the book was designed precisely to support both researchers and managers,” he explained.
The chapters were structured around themes considered central to understanding and addressing the disease today, such as transmission dynamics, environmental and urban factors, clinical spectrum, surveillance and diagnosis, viral evolution, and prevention strategies.
The selection of authors prioritized scientific backgrounds, experience in surveillance, and work in strategic areas, seeking complementarity between different profiles.
Representing the IOCThe document is signed by scientists Ana Maria Bispo de Filippis, Myrna Cristina Bonaldo, and Rafael Maciel de Freitas, in addition to Marta Giovanetti herself.
"The book helps guide priorities, such as where to invest, interpret early signs, and how to transform data, including genomic data, into faster and more targeted answers," said Marta.
“Our goal was to produce material that wouldn't be restricted to academia, but that could also support managers and health services in formulating more effective responses to the current complexity of dengue fever,” added Claudia Nunes Duarte.
The material was published by Springer Nature, one of the world's leading scientific publishing groups. For Claudia, the choice of two Brazilian researchers to edit the publication demonstrates the international recognition of dengue research conducted in the country.
"Springer Nature is a very selective publisher when choosing its themes and editors. The fact that we were invited demonstrates the leading role of Brazil and the Fioc"Cruze in the study of the disease," he highlighted.
From the historical rescue of dengue fever to the molecular mechanisms that sustain viral circulation, the work constructs a narrative that helps to understand how the arbovirus has established itself as one of the most adaptable pathogens today.
The initial chapters trace the evolutionary and phylogenetic paths of the dengue virus and describe the global dispersal of different lineages, which began circulating simultaneously in various territories.
The work then moves on to the cellular and immunological scale, detailing the interactions between virus and host, as well as the mechanisms that influence the clinical severity of the infection.
In parallel, it discusses the evolution of diagnostic techniques, vaccines, and antiviral strategies, reflecting the ongoing scientific effort to keep pace with the virus's adaptive capacity.
The discussion also brings vector surveillance, climate change, and genomic monitoring into the debate, highlighting that the evolution of dengue fever is not limited to biological aspects, but also involves environmental and social factors.
Throughout the chapters, the discussion focuses on disordered urban growth, human mobility, and adaptation to... Aedes aegypti These factors are emerging as creating increasingly favorable conditions for viral circulation, increasing the risk of large-scale epidemics.
On the other hand, the book highlights important advances in Brazil's capacity to produce applied science, expand surveillance networks, and incorporate genomics and integrated analysis into the routine of health services.
According to Marta, this movement paves the way for faster and more focused responses, as well as promoting innovation in vector control strategies and monitoring tools.
"There is room to strengthen evidence-based territorial responses, invest in new surveillance approaches, and transform data into concrete action," he reflected.
Claudia points out that, in 2024, Brazil recorded a historic peak in dengue cases, accompanied by an increase in mortality. For her, in this context of intensified transmission and greater epidemiological complexity, the book emerges as a strategic contribution to improving scientific and institutional responses.
"This work brings together the most up-to-date information in terms of research, vaccines, diagnosis, prophylaxis, and surveillance, contributing to addressing knowledge gaps and supporting more effective responses," he concluded.
Evolution of the dengue virus: from emergence to a global health crisis – Insights into genomics, ecology, and epidemiology
Springer Nature
389 pages
How to acquire:
• SpringerLink Platform (eBook and PDF, via institutional access or individual purchase)
• Springer Nature online store
The non-profit reproduction of the text is allowed as long as the source is cited (Comunicação / Instituto Oswaldo Cruz)
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